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Glucocorticoids can induce BIM to trigger apoptosis in the absence of BAX and BAK1
Cells from two murine lymphoid lines died 24–48 h after treatment with the glucocorticoid dexamethasone. Deletion of Bax and Bak1 prevented rapid apoptosis, but treatment with dexamethasone for greater 6 days still led to cell death that was characterized by release of cytochrome c into the cytosol,...
Guardat en:
| Publicat a: | Cell Death Dis |
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| Autors principals: | , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Nature Publishing Group UK
2020
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7280233/ https://ncbi.nlm.nih.gov/pubmed/32513923 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-020-2599-5 |
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