Paclitaxel-Induced Apoptosis Is BAK-Dependent, but BAX and BIM-Independent in Breast Tumor

Paclitaxel (Taxol)-induced cell death requires the intrinsic cell death pathway, but the specific participants and the precise mechanisms are poorly understood. Previous studies indicate that a BH3-only protein BIM (BCL-2 Interacting Mediator of cell death) plays a role in paclitaxel-induced apoptos...

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Detalhes bibliográficos
Main Authors: Miller, Anna V., Hicks, Mark A., Nakajima, Wataru, Richardson, Amanda C., Windle, Jolene J., Harada, Hisashi
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3618047/
https://ncbi.nlm.nih.gov/pubmed/23577147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0060685
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