Prevalence of mutations in the Plasmodium falciparum chloroquine resistance transporter, PfCRT, and association with ex vivo susceptibility to common anti-malarial drugs against African Plasmodium falciparum isolates

BACKGROUND: The Plasmodium falciparum chloroquine transporter gene (pfcrt) is known to be involved in chloroquine and amodiaquine resistance, and more particularly the mutations on the loci 72 to 76 localized within the second exon. Additionally, new mutations (T93S, H97Y, C101F, F145I, M343L, C350R...

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Dades bibliogràfiques
Publicat a:Malar J
Autors principals: Foguim, Francis Tsombeng, Bogreau, Hervé, Gendrot, Mathieu, Mosnier, Joel, Fonta, Isabelle, Benoit, Nicolas, Amalvict, Rémy, Madamet, Marylin, Wein, Sharon, Pradines, Bruno
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2020
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7275453/
https://ncbi.nlm.nih.gov/pubmed/32503540
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12936-020-03281-x
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