Prevalence of mutations in the Plasmodium falciparum chloroquine resistance transporter, PfCRT, and association with ex vivo susceptibility to common anti-malarial drugs against African Plasmodium falciparum isolates

BACKGROUND: The Plasmodium falciparum chloroquine transporter gene (pfcrt) is known to be involved in chloroquine and amodiaquine resistance, and more particularly the mutations on the loci 72 to 76 localized within the second exon. Additionally, new mutations (T93S, H97Y, C101F, F145I, M343L, C350R...

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Detalles Bibliográficos
Publicado en:Malar J
Main Authors: Foguim, Francis Tsombeng, Bogreau, Hervé, Gendrot, Mathieu, Mosnier, Joel, Fonta, Isabelle, Benoit, Nicolas, Amalvict, Rémy, Madamet, Marylin, Wein, Sharon, Pradines, Bruno
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2020
Assuntos:
Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7275453/
https://ncbi.nlm.nih.gov/pubmed/32503540
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12936-020-03281-x
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