HIV envelope trimer-elicited autologous neutralizing antibodies bind a region overlapping the N332 glycan supersite

To date, immunization studies of rabbits with the BG505 SOSIP.664 HIV envelope glycoprotein trimers have revealed the 241/289 glycan hole as the dominant neutralizing antibody epitope. Here, we isolated monoclonal antibodies from a rabbit that did not exhibit glycan hole–dependent autologous serum n...

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Publicat a:Sci Adv
Autors principals: Nogal, Bartek, McCoy, Laura E., van Gils, Marit J., Cottrell, Christopher A., Voss, James E., Andrabi, Raiees, Pauthner, Matthias, Liang, Chi-Hui, Messmer, Terrence, Nedellec, Rebecca, Shin, Mia, Turner, Hannah L., Ozorowski, Gabriel, Sanders, Rogier W., Burton, Dennis R., Ward, Andrew B.
Format: Artigo
Idioma:Inglês
Publicat: American Association for the Advancement of Science 2020
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7274786/
https://ncbi.nlm.nih.gov/pubmed/32548265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aba0512
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