Differential processing of HIV envelope glycans on the virus and soluble recombinant trimer

As the sole target of broadly neutralizing antibodies (bnAbs) to HIV, the envelope glycoprotein (Env) trimer is the focus of vaccination strategies designed to elicit protective bnAbs in humans. Because HIV Env is densely glycosylated with 75–90 N-glycans per trimer, most bnAbs use or accommodate th...

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Publicado en:Nat Commun
Autores principales: Cao, Liwei, Pauthner, Matthias, Andrabi, Raiees, Rantalainen, Kimmo, Berndsen, Zachary, Diedrich, Jolene K., Menis, Sergey, Sok, Devin, Bastidas, Raiza, Park, Sung-Kyu Robin, Delahunty, Claire M., He, Lin, Guenaga, Javier, Wyatt, Richard T., Schief, William R., Ward, Andrew B., Yates, John R., Burton, Dennis R., Paulson, James C.
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2018
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6135743/
https://ncbi.nlm.nih.gov/pubmed/30209313
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-06121-4
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