Mitochondrial 8-oxoguanine DNA glycosylase mitigates alveolar epithelial cell PINK1 deficiency, mitochondrial DNA damage, apoptosis, and lung fibrosis

Alveolar epithelial cell (AEC) apoptosis, arising from mitochondrial dysfunction and mitophagy defects, is important in mediating idiopathic pulmonary fibrosis (IPF). Our group established a role for the mitochondrial (mt) DNA base excision repair enzyme, 8-oxoguanine-DNA glycosylase 1 (mtOGG1), in...

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Detalhes bibliográficos
Publicado no:Am J Physiol Lung Cell Mol Physiol
Main Authors: Kim, Seok-Jo, Cheresh, Paul, Jablonski, Renea P., Rachek, Lyudmila, Yeldandi, Anjana, Piseaux-Aillon, Raul, Ciesielski, Mark J., Ridge, Karen, Gottardi, Cara, Lam, Anna P., Pardo, Annie, Selman, Moises, Natarajan, Viswanathan, Kamp, David W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7272732/
https://ncbi.nlm.nih.gov/pubmed/32209025
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00069.2019
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