Mitochondrial catalase overexpressed transgenic mice are protected against lung fibrosis in part via preventing alveolar epithelial cell mitochondrial DNA damage

RATIONALE: Alveolar epithelial cell (AEC) injury and mitochondrial dysfunction are important in the development of lung fibrosis. Our group has shown that in the asbestos exposed lung, the generation of mitochondrial reactive oxygen species (ROS) in AEC mediate mitochondrial DNA (mtDNA) damage and a...

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Publicado en:Free Radic Biol Med
Autores principales: Kim, Seok-Jo, Cheresh, Paul, Jablonski, Renea P., Morales-Nebreda, Luisa, Cheng, Yuan, Hogan, Erin, Yeldandi, Anjana, Chi, Monica, Piseaux, Raul, Ridge, Karen, Hart, C. Michael, Chandel, Navdeep, Budinger, G.R. Scott, Kamp, David W.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2016
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5928521/
https://ncbi.nlm.nih.gov/pubmed/27840320
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2016.11.007
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