Mitochondrial catalase overexpressed transgenic mice are protected against lung fibrosis in part via preventing alveolar epithelial cell mitochondrial DNA damage

RATIONALE: Alveolar epithelial cell (AEC) injury and mitochondrial dysfunction are important in the development of lung fibrosis. Our group has shown that in the asbestos exposed lung, the generation of mitochondrial reactive oxygen species (ROS) in AEC mediate mitochondrial DNA (mtDNA) damage and a...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Free Radic Biol Med
Päätekijät: Kim, Seok-Jo, Cheresh, Paul, Jablonski, Renea P., Morales-Nebreda, Luisa, Cheng, Yuan, Hogan, Erin, Yeldandi, Anjana, Chi, Monica, Piseaux, Raul, Ridge, Karen, Hart, C. Michael, Chandel, Navdeep, Budinger, G.R. Scott, Kamp, David W.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2016
Aiheet:
Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5928521/
https://ncbi.nlm.nih.gov/pubmed/27840320
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2016.11.007
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