Mitochondrial 8-oxoguanine DNA glycosylase mitigates alveolar epithelial cell PINK1 deficiency, mitochondrial DNA damage, apoptosis, and lung fibrosis

Alveolar epithelial cell (AEC) apoptosis, arising from mitochondrial dysfunction and mitophagy defects, is important in mediating idiopathic pulmonary fibrosis (IPF). Our group established a role for the mitochondrial (mt) DNA base excision repair enzyme, 8-oxoguanine-DNA glycosylase 1 (mtOGG1), in...

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Publicat a:Am J Physiol Lung Cell Mol Physiol
Autors principals: Kim, Seok-Jo, Cheresh, Paul, Jablonski, Renea P., Rachek, Lyudmila, Yeldandi, Anjana, Piseaux-Aillon, Raul, Ciesielski, Mark J., Ridge, Karen, Gottardi, Cara, Lam, Anna P., Pardo, Annie, Selman, Moises, Natarajan, Viswanathan, Kamp, David W.
Format: Artigo
Idioma:Inglês
Publicat: American Physiological Society 2020
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7272732/
https://ncbi.nlm.nih.gov/pubmed/32209025
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00069.2019
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