Mitochondrial 8-oxoguanine DNA glycosylase mitigates alveolar epithelial cell PINK1 deficiency, mitochondrial DNA damage, apoptosis, and lung fibrosis

Alveolar epithelial cell (AEC) apoptosis, arising from mitochondrial dysfunction and mitophagy defects, is important in mediating idiopathic pulmonary fibrosis (IPF). Our group established a role for the mitochondrial (mt) DNA base excision repair enzyme, 8-oxoguanine-DNA glycosylase 1 (mtOGG1), in...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:Am J Physiol Lung Cell Mol Physiol
मुख्य लेखकों: Kim, Seok-Jo, Cheresh, Paul, Jablonski, Renea P., Rachek, Lyudmila, Yeldandi, Anjana, Piseaux-Aillon, Raul, Ciesielski, Mark J., Ridge, Karen, Gottardi, Cara, Lam, Anna P., Pardo, Annie, Selman, Moises, Natarajan, Viswanathan, Kamp, David W.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: American Physiological Society 2020
विषय:
Research Article
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC7272732/
https://ncbi.nlm.nih.gov/pubmed/32209025
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00069.2019
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