Mitochondrial 8-oxoguanine DNA glycosylase mitigates alveolar epithelial cell PINK1 deficiency, mitochondrial DNA damage, apoptosis, and lung fibrosis

Alveolar epithelial cell (AEC) apoptosis, arising from mitochondrial dysfunction and mitophagy defects, is important in mediating idiopathic pulmonary fibrosis (IPF). Our group established a role for the mitochondrial (mt) DNA base excision repair enzyme, 8-oxoguanine-DNA glycosylase 1 (mtOGG1), in...

Descrición completa

Gardado en:
Detalles Bibliográficos
Publicado en:Am J Physiol Lung Cell Mol Physiol
Main Authors: Kim, Seok-Jo, Cheresh, Paul, Jablonski, Renea P., Rachek, Lyudmila, Yeldandi, Anjana, Piseaux-Aillon, Raul, Ciesielski, Mark J., Ridge, Karen, Gottardi, Cara, Lam, Anna P., Pardo, Annie, Selman, Moises, Natarajan, Viswanathan, Kamp, David W.
Formato: Artigo
Idioma:Inglês
Publicado: American Physiological Society 2020
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7272732/
https://ncbi.nlm.nih.gov/pubmed/32209025
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00069.2019
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares