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DNA Sequence Context Effects on the Glycosylase Activity of Human 8-Oxoguanine DNA Glycosylase

Human 8-oxoguanine DNA glycosylase (OGG1) is a key enzyme involved in removing 7,8-dihydro-8-oxoguanine (8-oxoG), a highly mutagenic DNA lesion generated by oxidative stress. The removal of 8-oxoG by OGG1 is affected by the local DNA sequence, and this feature most likely contributes to observed mut...

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Detalhes bibliográficos
Main Authors: Sassa, Akira, Beard, William A., Prasad, Rajendra, Wilson, Samuel H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3481274/
https://ncbi.nlm.nih.gov/pubmed/22989888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.397786
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