Impact of Ribonucleotide Backbone on Translesion Synthesis and Repair of 7,8-Dihydro-8-oxoguanine

Numerous ribonucleotides are incorporated into the genome during DNA replication. Oxidized ribonucleotides can also be erroneously incorporated into DNA. Embedded ribonucleotides destabilize the structure of DNA and retard DNA synthesis by DNA polymerases (pols), leading to genomic instability. Mamm...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Sassa, Akira, Çağlayan, Melike, Rodriguez, Yesenia, Beard, William A., Wilson, Samuel H., Nohmi, Takehiko, Honma, Masamitsu, Yasui, Manabu
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2016
Subjects:
DNA and Chromosomes
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5104951/
https://ncbi.nlm.nih.gov/pubmed/27660390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.738732
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