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Structural and Biochemical Analysis of DNA Helix Invasion by the Bacterial 8-Oxoguanine DNA Glycosylase MutM

MutM is a bacterial DNA glycosylase that serves as the first line of defense against the highly mutagenic 8-oxoguanine (oxoG) lesion, catalyzing glycosidic bond cleavage of oxoG to initiate base excision DNA repair. Previous work has shown that MutM actively interrogates DNA for the presence of an i...

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Bibliografski detalji
Glavni autori: Sung, Rou-Jia, Zhang, Michael, Qi, Yan, Verdine, Gregory L.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2013
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3617240/
https://ncbi.nlm.nih.gov/pubmed/23404556
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.415612
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