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Sequence-dependent Structural Variation in DNA Undergoing Intrahelical Inspection by the DNA glycosylase MutM

MutM, a bacterial DNA-glycosylase, plays a critical role in maintaining genome integrity by catalyzing glycosidic bond cleavage of 8-oxoguanine (oxoG) lesions to initiate base excision DNA repair. The task faced by MutM of locating rare oxoG residues embedded in an overwhelming excess of undamaged b...

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Библиографические подробности
Главные авторы: Sung, Rou-Jia, Zhang, Michael, Qi, Yan, Verdine, Gregory L.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Biochemistry and Molecular Biology 2012
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3365742/
https://ncbi.nlm.nih.gov/pubmed/22465958
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.313635
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