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Structural Basis for the Lesion-scanning Mechanism of the MutY DNA Glycosylase

The highly mutagenic A:8-oxoguanine (oxoG) base pair is generated mainly by misreplication of the C:oxoG base pair, the oxidation product of the C:G base pair. The A:oxoG base pair is particularly insidious because neither base in it carries faithful information to direct the repair of the other. Th...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Wang, Lan, Chakravarthy, Srinivas, Verdine, Gregory L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5377813/
https://ncbi.nlm.nih.gov/pubmed/28130451
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.757039
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