Structural basis for finding OG lesions and avoiding undamaged G by the DNA glycosylase MutY

The adenine glycosylase MutY selectively initiates repair of OG:A lesions and, by comparison, avoids G:A mispairs. The ability to distinguish these closely related substrates relies on the C-terminal domain of MutY which structurally resembles MutT. To understand the mechanism for substrate specific...

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Udgivet i:ACS Chem Biol
Main Authors: Russelburg, L. Peyton, Murray, Valerie L. O’Shea, Demir, Merve, Knutsen, Kyle R., Sehgal, Sonia L., Cao, Sheng, David, Sheila S., Horvath, Martin P.
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7069122/
https://ncbi.nlm.nih.gov/pubmed/31829624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.9b00639
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