FGFR inhibition enhances sensitivity to radiation in non-small cell lung cancer.

Fibroblast growth factor receptors (FGFR) are commonly altered in non-small cell lung cancer (NSCLC). FGFRs activate multiple pathways including RAS/RAF/MAPK, PI3K/AKT and STAT, which may play a role in the cellular response to radiation. We investigated the effects of combining the selective FGFR 1...

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Publicat a:Mol Cancer Ther
Autors principals: SenthilKumar, Gopika, Fisher, Michael M., Skiba, Justin H., Miller, Margot C., Brennan, Sean R., Kaushik, Saakshi, Bradley, Samantha T., Longhurst, Colin A., Buehler, Darya, Nickel, Kwangok P., Iyer, Gopal, Kimple, Randall J., Baschnagel, Andrew M.
Format: Artigo
Idioma:Inglês
Publicat: 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7272291/
https://ncbi.nlm.nih.gov/pubmed/32371583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-19-0931
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