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Fibroblast Growth Factor Receptors as Targets for Radiosensitization in Head and Neck Squamous Cell Carcinomas

PURPOSE: We examined the capacity of the pan-fibroblast growth factor receptor (FGFR) inhibitor AZD4547 to augment radiation response across a panel of head and neck squamous cell carcinoma (HNSCC) cell lines and xenografts. EXPERIMENTAL DESIGN: FGFR1, FGFR2, FGFR3 RNA in situ hybridization (ISH) ex...

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Détails bibliographiques
Publié dans:Int J Radiat Oncol Biol Phys
Auteurs principaux: Fisher, Michael M., SenthilKumar, Gopika, Hu, Rong, Goldstein, Steve, Ong, Irene, Miller, Margot, Brennan, Sean R., Kaushik, Saakshi, Abel, Lindsey, Nickel, Kwangok P., Iyer, Gopal, Harari, Paul M., Kimple, Randall J., Baschnagel, Andrew M.
Format: Artigo
Langue:Inglês
Publié: 2020
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7321889/
https://ncbi.nlm.nih.gov/pubmed/32298810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijrobp.2020.03.040
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