Small RNA-mediated transgenerational silencing of histone genes impairs fertility in piRNA mutants

PIWI-interacting RNAs (piRNAs) promote fertility in many animals. Yet, whether this is due to their conserved role in repressing repetitive elements (REs) remains unclear. Here, we show that the progressive loss of fertility in Caenorhabditis elegans lacking piRNAs is not caused by derepression of R...

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Gepubliceerd in:Nat Cell Biol
Hoofdauteurs: Barucci, Giorgia, Cornes, Eric, Singh, Meetali, Li, Blaise, Ugolini, Martino, Samolygo, Aleksei, Didier, Celine, Dingli, Florent, Loew, Damarys, Quarato, Piergiuseppe, Cecere, Germano
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2020
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7272227/
https://ncbi.nlm.nih.gov/pubmed/32015436
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41556-020-0462-7
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