Small RNA-mediated transgenerational silencing of histone genes impairs fertility in piRNA mutants

PIWI-interacting RNAs (piRNAs) promote fertility in many animals. Yet, whether this is due to their conserved role in repressing repetitive elements (REs) remains unclear. Here, we show that the progressive loss of fertility in Caenorhabditis elegans lacking piRNAs is not caused by derepression of R...

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Udgivet i:Nat Cell Biol
Main Authors: Barucci, Giorgia, Cornes, Eric, Singh, Meetali, Li, Blaise, Ugolini, Martino, Samolygo, Aleksei, Didier, Celine, Dingli, Florent, Loew, Damarys, Quarato, Piergiuseppe, Cecere, Germano
Format: Artigo
Sprog:Inglês
Udgivet: 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7272227/
https://ncbi.nlm.nih.gov/pubmed/32015436
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41556-020-0462-7
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