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The piRNA targeting rules and the resistance to piRNA silencing in endogenous genes
piRNAs silence transposons to safeguard genome integrity in animals. However, the functions of the many piRNAs that do not map to transposons remain unknown. Here we showed that piRNA targeting in C. elegans can tolerate a few mismatches but prefer perfect pairing at the seed region. The broad targe...
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| Publicado no: | Science |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5939965/ https://ncbi.nlm.nih.gov/pubmed/29420292 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aao2840 |
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