The piRNA targeting rules and the resistance to piRNA silencing in endogenous genes

piRNAs silence transposons to safeguard genome integrity in animals. However, the functions of the many piRNAs that do not map to transposons remain unknown. Here we showed that piRNA targeting in C. elegans can tolerate a few mismatches but prefer perfect pairing at the seed region. The broad targe...

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Bibliographic Details
Published in:Science
Main Authors: Zhang, Donglei, Tu, Shikui, Stubna, Michael, Wu, Wei-Sheng, Huang, Wei-Che, Weng, Zhiping, Lee, Heng-Chi
Format: Artigo
Language:Inglês
Published: 2018
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5939965/
https://ncbi.nlm.nih.gov/pubmed/29420292
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aao2840
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