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S100A1 blocks the interaction between p53 and mdm2 and decreases cell proliferation activity
About 50% of human cancers across the globe arise due to a mutation in the p53 gene which gives rise to its functional inactive form, and in the rest of the cancer the efficacy of active p53 (wild-type) is hindered by MDM2-mediated degradation. Breakdown of the p53-MDM2 association may constitute an...
Gorde:
| Argitaratua izan da: | PLoS One |
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| Egile Nagusiak: | , , |
| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
Public Library of Science
2020
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7272100/ https://ncbi.nlm.nih.gov/pubmed/32497081 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0234152 |
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