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Amlexanox Blocks the Interaction between S100A4 and Epidermal Growth Factor and Inhibits Cell Proliferation

The human S100A4 protein binds calcium, resulting in a change in its conformation to promote the interaction with its target protein. Human epidermal growth factor (EGF) is the target protein of S100A4 and a critical ligand of the receptor EGFR. The EGF/EGFR system promotes cell survival, differenti...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Cho, Ching Chang, Chou, Ruey-Hwang, Yu, Chin
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4999211/
https://ncbi.nlm.nih.gov/pubmed/27559743
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0161663
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