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Traceless native chemical ligation of lipid-modified peptide surfactants by mixed micelle formation

Biology utilizes multiple strategies, including sequestration in lipid vesicles, to raise the rate and specificity of chemical reactions through increases in effective molarity of reactants. We show that micelle-assisted reaction can facilitate native chemical ligations (NCLs) between a peptide-thio...

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Pubblicato in:Nat Commun
Autori principali: Jin, Shuaijiang, Brea, Roberto J., Rudd, Andrew K., Moon, Stuart P., Pratt, Matthew R., Devaraj, Neal K.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2020
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7270136/
https://ncbi.nlm.nih.gov/pubmed/32493905
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-16595-w
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