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Traceless synthesis of ceramides in living cells reveals saturation-dependent apoptotic effects

Mammalian cells synthesize thousands of distinct lipids, yet the function of many of these lipid species is unknown. Ceramides, a class of sphingolipid, are implicated in several cell-signaling pathways but poor cell permeability and lack of selectivity in endogenous synthesis pathways have hampered...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Rudd, Andrew K., Devaraj, Neal K.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6055205/
https://ncbi.nlm.nih.gov/pubmed/29967152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1804266115
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