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Traceless native chemical ligation of lipid-modified peptide surfactants by mixed micelle formation

Biology utilizes multiple strategies, including sequestration in lipid vesicles, to raise the rate and specificity of chemical reactions through increases in effective molarity of reactants. We show that micelle-assisted reaction can facilitate native chemical ligations (NCLs) between a peptide-thio...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Jin, Shuaijiang, Brea, Roberto J., Rudd, Andrew K., Moon, Stuart P., Pratt, Matthew R., Devaraj, Neal K.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7270136/
https://ncbi.nlm.nih.gov/pubmed/32493905
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-16595-w
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