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VapBC22 toxin-antitoxin system from Mycobacterium tuberculosis is required for pathogenesis and modulation of host immune response

Virulence-associated protein B and C toxin-antitoxin (TA) systems are widespread in prokaryotes, but their precise role in physiology is poorly understood. We have functionally characterized the VapBC22 TA system from Mycobacterium tuberculosis. Transcriptome analysis revealed that overexpression of...

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Publicat a:Sci Adv
Autors principals: Agarwal, Sakshi, Sharma, Arun, Bouzeyen, Rania, Deep, Amar, Sharma, Harsh, Mangalaparthi, Kiran K., Datta, Keshava K., Kidwai, Saqib, Gowda, Harsha, Varadarajan, Raghavan, Sharma, Ravi Datta, Thakur, Krishan Gopal, Singh, Ramandeep
Format: Artigo
Idioma:Inglês
Publicat: American Association for the Advancement of Science 2020
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7269643/
https://ncbi.nlm.nih.gov/pubmed/32537511
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aba6944
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