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Structural, functional and biological insights into the role of Mycobacterium tuberculosis VapBC11 toxin–antitoxin system: targeting a tRNase to tackle mycobacterial adaptation

Toxin–antitoxin (TA) systems are involved in diverse physiological processes in prokaryotes, but their exact role in Mycobacterium tuberculosis (Mtb) virulence and in vivo stress adaptation has not been extensively studied. Here, we demonstrate that the VapBC11 TA module is essential for Mtb to esta...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:Nucleic Acids Res
Main Authors: Deep, Amar, Tiwari, Prabhakar, Agarwal, Sakshi, Kaundal, Soni, Kidwai, Saqib, Singh, Ramandeep, Thakur, Krishan G
פורמט: Artigo
שפה:Inglês
יצא לאור: Oxford University Press 2018
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC6265470/
https://ncbi.nlm.nih.gov/pubmed/30329074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky924
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