Pharmacokinetics-Pharmacodynamics of Enmetazobactam Combined with Cefepime in a Neutropenic Murine Thigh Infection Model

Third-generation cephalosporin (3GC)-resistant Enterobacteriaceae are classified as critical priority pathogens, with extended-spectrum β-lactamases (ESBLs) as principal resistance determinants. Enmetazobactam (formerly AAI101) is a novel ESBL inhibitor developed in combination with cefepime for emp...

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Bibliographische Detailangaben
Veröffentlicht in:Antimicrob Agents Chemother
Hauptverfasser: Bernhard, Fabian, Odedra, Rajesh, Sordello, Sylvie, Cardin, Rossella, Franzoni, Samantha, Charrier, Cédric, Belley, Adam, Warn, Peter, Machacek, Matthias, Knechtle, Philipp
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2020
Schlagworte:
Pharmacology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7269482/
https://ncbi.nlm.nih.gov/pubmed/32253212
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00078-20
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