Pharmacodynamics of Cefepime Combined with Tazobactam against Clinically Relevant Enterobacteriaceae in a Neutropenic Mouse Thigh Model

The lack of new antibiotics has prompted investigation of the combination of two existing agents—cefepime, a broad-spectrum cephalosporin, and tazobactam—to broaden their efficacy against extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae. We determined the pharmacokinetic (PK) and...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Melchers, Maria J., van Mil, Anita C., Lagarde, Claudia, den Hartigh, Jan, Mouton, Johan W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2017
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5571283/
https://ncbi.nlm.nih.gov/pubmed/28630197
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00267-17
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