Structure-Guided Mutagenesis Alters Deubiquitinating Activity and Attenuates Pathogenesis of a Murine Coronavirus

Coronaviruses express a multifunctional papain-like protease, termed papain-like protease 2 (PLP2). PLP2 acts as a protease that cleaves the viral replicase polyprotein and as a deubiquitinating (DUB) enzyme which removes ubiquitin (Ub) moieties from ubiquitin-conjugated proteins. Previous in vitro...

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Vydáno v:J Virol
Hlavní autoři: Deng, Xufang, Chen, Yafang, Mielech, Anna M., Hackbart, Matthew, Kesely, Kristina R., Mettelman, Robert C., O’Brien, Amornrat, Chapman, Mackenzie E., Mesecar, Andrew D., Baker, Susan C.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2020
Témata:
Pathogenesis and Immunity
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7269429/
https://ncbi.nlm.nih.gov/pubmed/32188728
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01734-19
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