Coronavirus nonstructural protein 15 mediates evasion of dsRNA sensors and limits apoptosis in macrophages

Coronaviruses are positive-sense RNA viruses that generate double-stranded RNA (dsRNA) intermediates during replication, yet evade detection by host innate immune sensors. Here we report that coronavirus nonstructural protein 15 (nsp15), an endoribonuclease, is required for evasion of dsRNA sensors....

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Deng, Xufang, Hackbart, Matthew, Mettelman, Robert C., O’Brien, Amornrat, Mielech, Anna M., Yi, Guanghui, Kao, C. Cheng, Baker, Susan C.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2017
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5448190/
https://ncbi.nlm.nih.gov/pubmed/28484023
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1618310114
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