Coronavirus nonstructural protein 15 mediates evasion of dsRNA sensors and limits apoptosis in macrophages

Coronaviruses are positive-sense RNA viruses that generate double-stranded RNA (dsRNA) intermediates during replication, yet evade detection by host innate immune sensors. Here we report that coronavirus nonstructural protein 15 (nsp15), an endoribonuclease, is required for evasion of dsRNA sensors....

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Deng, Xufang, Hackbart, Matthew, Mettelman, Robert C., O’Brien, Amornrat, Mielech, Anna M., Yi, Guanghui, Kao, C. Cheng, Baker, Susan C.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2017
Fag:
PNAS Plus
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5448190/
https://ncbi.nlm.nih.gov/pubmed/28484023
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1618310114
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