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Kinetic mechanism for viral dsRNA length discrimination by MDA5 filaments
The viral sensor MDA5 distinguishes between cellular and viral dsRNAs by length-dependent recognition in the range of ∼0.5–7 kb. The ability to discriminate dsRNA length at this scale sets MDA5 apart from other dsRNA receptors of the immune system. We have shown previously that MDA5 forms filaments...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3523859/ https://ncbi.nlm.nih.gov/pubmed/23129641 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1208618109 |
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