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Cooperative assembly and dynamic disassembly of MDA5 filaments for viral dsRNA recognition
MDA5, an RIG-I-like helicase, is a conserved cytoplasmic viral RNA sensor, which recognizes dsRNA from a wide-range of viruses in a length-dependent manner. It has been proposed that MDA5 forms higher-order structures upon viral dsRNA recognition or during antiviral signaling, however the organizati...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
National Academy of Sciences
2011
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3248507/ https://ncbi.nlm.nih.gov/pubmed/22160685 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1113651108 |
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