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Cryo-EM Structures of MDA5-dsRNA Filaments at Different Stages of ATP Hydrolysis
Double-stranded RNA (dsRNA) is a potent proinflammatory signature of viral infection. Long cytosolic dsRNA is recognized by MDA5. The cooperative assembly of MDA5 into helical filaments on dsRNA nucleates the assembly of a multiprotein type I interferon signaling platform. Here, we determined cryoel...
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| Udgivet i: | Mol Cell |
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| Main Authors: | , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Cell Press
2018
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6310684/ https://ncbi.nlm.nih.gov/pubmed/30449722 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2018.10.012 |
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