RNA editing by ADAR1 prevents MDA5 sensing of endogenous dsRNA as nonself

Adenosine-to-inosine (A-to-I) editing is a highly prevalent posttranscriptional modification of RNA, mediated by ADAR (adenosine deaminase acting on RNA) enzymes. In addition to RNA editing, additional functions have been proposed for ADAR1. To determine the specific role of RNA editing by ADAR1, we...

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Bibliografske podrobnosti
izdano v:Science
Main Authors: Liddicoat, Brian J., Piskol, Robert, Chalk, Alistair M., Ramaswami, Gokul, Higuchi, Miyoko, Hartner, Jochen C., Li, Jin Billy, Seeburg, Peter H., Walkley, Carl R.
Format: Artigo
Jezik:Inglês
Izdano: 2015
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5444807/
https://ncbi.nlm.nih.gov/pubmed/26275108
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aac7049
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