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RNA editing by ADAR1 prevents MDA5 sensing of endogenous dsRNA as nonself
Adenosine-to-inosine (A-to-I) editing is a highly prevalent posttranscriptional modification of RNA, mediated by ADAR (adenosine deaminase acting on RNA) enzymes. In addition to RNA editing, additional functions have been proposed for ADAR1. To determine the specific role of RNA editing by ADAR1, we...
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| Veröffentlicht in: | Science |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2015
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5444807/ https://ncbi.nlm.nih.gov/pubmed/26275108 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aac7049 |
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