Adenosine-to-inosine RNA editing by ADAR1 is essential for normal murine erythropoiesis

Adenosine deaminases that act on RNA (ADARs) convert adenosine residues to inosine in double-stranded RNA. In vivo, ADAR1 is essential for the maintenance of hematopoietic stem/progenitors. Whether other hematopoietic cell types also require ADAR1 has not been assessed. Using erythroid- and myeloid-...

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Publicat a:Exp Hematol
Autors principals: Liddicoat, Brian J., Hartner, Jochen C., Piskol, Robert, Ramaswami, Gokul, Chalk, Alistair M., Kingsley, Paul D., Sankaran, Vijay G., Wall, Meaghan, Purton, Louise E., Seeburg, Peter H., Palis, James, Orkin, Stuart H., Lu, Jun, Li, Jin Billy, Walkley, Carl R.
Format: Artigo
Idioma:Inglês
Publicat: 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5035604/
https://ncbi.nlm.nih.gov/pubmed/27373493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exphem.2016.06.250
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