Adenosine-to-inosine RNA editing by ADAR1 is essential for normal murine erythropoiesis

Adenosine deaminases that act on RNA (ADARs) convert adenosine residues to inosine in double-stranded RNA. In vivo, ADAR1 is essential for the maintenance of hematopoietic stem/progenitors. Whether other hematopoietic cell types also require ADAR1 has not been assessed. Using erythroid- and myeloid-...

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Gepubliceerd in:Exp Hematol
Hoofdauteurs: Liddicoat, Brian J., Hartner, Jochen C., Piskol, Robert, Ramaswami, Gokul, Chalk, Alistair M., Kingsley, Paul D., Sankaran, Vijay G., Wall, Meaghan, Purton, Louise E., Seeburg, Peter H., Palis, James, Orkin, Stuart H., Lu, Jun, Li, Jin Billy, Walkley, Carl R.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2016
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5035604/
https://ncbi.nlm.nih.gov/pubmed/27373493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exphem.2016.06.250
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