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RNA editing by ADAR1 marks dsRNA as “self”

A paper recently published in Science reports that adenosine deaminase acting on RNA 1-dependent adenosine-to-inosine editing marks endogenous double strand RNA as self and prevents their immune recognition by cytosolic RNA sensor MDA5.

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Detalhes bibliográficos
Publicado no:Cell Res
Main Authors: Yu, Zhou, Chen, Taoyong, Cao, Xuetao
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4670992/
https://ncbi.nlm.nih.gov/pubmed/26596786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cr.2015.135
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