An RNA editing/dsRNA binding-independent gene regulatory mechanism of ADARs and its clinical implication in cancer

Adenosine-to-inosine (A-to-I) RNA editing, catalyzed by Adenosine DeAminases acting on double-stranded RNA(dsRNA) (ADAR), occurs predominantly in the 3′ untranslated regions (3′UTRs) of spliced mRNA. Here we uncover an unanticipated link between ADARs (ADAR1 and ADAR2) and the expression of target g...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Nucleic Acids Res
Prif Awduron: Qi, Lihua, Song, Yangyang, Chan, Tim Hon Man, Yang, Henry, Lin, Chi Ho, Tay, Daryl Jin Tai, Hong, HuiQi, Tang, Sze Jing, Tan, Kar Tong, Huang, Xi Xiao, Lin, Jaymie Siqi, Ng, Vanessa Hui En, Maury, Julien Jean Pierre, Tenen, Daniel G., Chen, Leilei
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Oxford University Press 2017
Pynciau:
Gene regulation, Chromatin and Epigenetics
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5737565/
https://ncbi.nlm.nih.gov/pubmed/28985428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx667
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