An RNA editing/dsRNA binding-independent gene regulatory mechanism of ADARs and its clinical implication in cancer

Adenosine-to-inosine (A-to-I) RNA editing, catalyzed by Adenosine DeAminases acting on double-stranded RNA(dsRNA) (ADAR), occurs predominantly in the 3′ untranslated regions (3′UTRs) of spliced mRNA. Here we uncover an unanticipated link between ADARs (ADAR1 and ADAR2) and the expression of target g...

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Pubblicato in:Nucleic Acids Res
Autori principali: Qi, Lihua, Song, Yangyang, Chan, Tim Hon Man, Yang, Henry, Lin, Chi Ho, Tay, Daryl Jin Tai, Hong, HuiQi, Tang, Sze Jing, Tan, Kar Tong, Huang, Xi Xiao, Lin, Jaymie Siqi, Ng, Vanessa Hui En, Maury, Julien Jean Pierre, Tenen, Daniel G., Chen, Leilei
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2017
Soggetti:
Gene regulation, Chromatin and Epigenetics
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5737565/
https://ncbi.nlm.nih.gov/pubmed/28985428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx667
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