An RNA editing/dsRNA binding-independent gene regulatory mechanism of ADARs and its clinical implication in cancer

Adenosine-to-inosine (A-to-I) RNA editing, catalyzed by Adenosine DeAminases acting on double-stranded RNA(dsRNA) (ADAR), occurs predominantly in the 3′ untranslated regions (3′UTRs) of spliced mRNA. Here we uncover an unanticipated link between ADARs (ADAR1 and ADAR2) and the expression of target g...

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Detalles Bibliográficos
Publicado en:Nucleic Acids Res
Main Authors: Qi, Lihua, Song, Yangyang, Chan, Tim Hon Man, Yang, Henry, Lin, Chi Ho, Tay, Daryl Jin Tai, Hong, HuiQi, Tang, Sze Jing, Tan, Kar Tong, Huang, Xi Xiao, Lin, Jaymie Siqi, Ng, Vanessa Hui En, Maury, Julien Jean Pierre, Tenen, Daniel G., Chen, Leilei
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2017
Assuntos:
Gene regulation, Chromatin and Epigenetics
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5737565/
https://ncbi.nlm.nih.gov/pubmed/28985428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx667
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