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MDA5 cooperatively forms dimers and ATP-sensitive filaments upon binding double-stranded RNA
Melanoma differentiation-associated gene-5 (MDA5) detects viral double-stranded RNA in the cytoplasm. RNA binding induces MDA5 to activate the signalling adaptor MAVS through interactions between the caspase recruitment domains (CARDs) of the two proteins. The molecular mechanism of MDA5 signalling...
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| Main Authors: | , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Nature Publishing Group
2012
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3321199/ https://ncbi.nlm.nih.gov/pubmed/22314235 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2012.19 |
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