PTPN22 phosphorylation acts as a molecular rheostat for the inhibition of TCR signaling

The hematopoietic-specific protein tyrosine phosphatase nonreceptor type 22 (PTPN22) is encoded by a major autoimmunity risk gene. PTPN22 inhibits T cell activation by dephosphorylating substrates involved in proximal T cell receptor (TCR) signaling. Here, we found by mass spectrometry that PTPN22 w...

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Vydáno v:Sci Signal
Hlavní autoři: Yang, Shen, Svensson, Mattias N.D., Harder, Nathaniel H. O., Hsieh, WanChen, Santelli, Eugenio, Kiosses, William B., Moresco, James J., Yates, John R., King, Charles C., Liu, Lin, Stanford, Stephanie M., Bottini, Nunzio
Médium: Artigo
Jazyk:Inglês
Vydáno: 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7263369/
https://ncbi.nlm.nih.gov/pubmed/32184287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aaw8130
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