ALS/FTD-associated protein FUS induces mitochondrial dysfunction by preferentially sequestering respiratory chain complex mRNAs

Dysregulation of the DNA/RNA-binding protein FUS causes certain subtypes of ALS/FTD by largely unknown mechanisms. Recent evidence has shown that FUS toxic gain of function due either to mutations or to increased expression can disrupt critical cellular processes, including mitochondrial functions....

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Detalhes bibliográficos
Publicado no:Genes Dev
Main Authors: Tsai, Yueh-Lin, Coady, Tristan H., Lu, Lei, Zheng, Dinghai, Alland, Isabel, Tian, Bin, Shneider, Neil A., Manley, James L.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2020
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7263147/
https://ncbi.nlm.nih.gov/pubmed/32381627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.335836.119
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