ALS/FTD-associated protein FUS induces mitochondrial dysfunction by preferentially sequestering respiratory chain complex mRNAs

Dysregulation of the DNA/RNA-binding protein FUS causes certain subtypes of ALS/FTD by largely unknown mechanisms. Recent evidence has shown that FUS toxic gain of function due either to mutations or to increased expression can disrupt critical cellular processes, including mitochondrial functions....

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Bibliografski detalji
Izdano u:Genes Dev
Glavni autori: Tsai, Yueh-Lin, Coady, Tristan H., Lu, Lei, Zheng, Dinghai, Alland, Isabel, Tian, Bin, Shneider, Neil A., Manley, James L.
Format: Artigo
Jezik:Inglês
Izdano: Cold Spring Harbor Laboratory Press 2020
Teme:
Research Paper
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7263147/
https://ncbi.nlm.nih.gov/pubmed/32381627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.335836.119
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