ALS/FTD-associated protein FUS induces mitochondrial dysfunction by preferentially sequestering respiratory chain complex mRNAs

Dysregulation of the DNA/RNA-binding protein FUS causes certain subtypes of ALS/FTD by largely unknown mechanisms. Recent evidence has shown that FUS toxic gain of function due either to mutations or to increased expression can disrupt critical cellular processes, including mitochondrial functions....

Полное описание

Сохранить в:
Библиографические подробности
Опубликовано в: :Genes Dev
Главные авторы: Tsai, Yueh-Lin, Coady, Tristan H., Lu, Lei, Zheng, Dinghai, Alland, Isabel, Tian, Bin, Shneider, Neil A., Manley, James L.
Формат: Artigo
Язык:Inglês
Опубликовано: Cold Spring Harbor Laboratory Press 2020
Предметы:
Research Paper
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7263147/
https://ncbi.nlm.nih.gov/pubmed/32381627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.335836.119
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!

Схожие документы