Generation and validation of structurally defined antibody–siRNA conjugates

Gene silencing by RNA interference (RNAi) has emerged as a powerful treatment strategy across a potentially broad range of diseases. Tailoring siRNAs to silence genes vital for cancer cell growth and function could be an effective treatment, but there are several challenges which must be overcome to...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Nanna, Alex R, Kel’in, Alexander V, Theile, Christopher, Pierson, Justin M, Voo, Zhi Xiang, Garg, Ashish, Nair, Jayaprakash K, Maier, Martin A, Fitzgerald, Kevin, Rader, Christoph
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
Chemical Biology and Nucleic Acid Chemistry
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7261152/
https://ncbi.nlm.nih.gov/pubmed/32347936
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa286
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