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Generation and validation of structurally defined antibody–siRNA conjugates

Gene silencing by RNA interference (RNAi) has emerged as a powerful treatment strategy across a potentially broad range of diseases. Tailoring siRNAs to silence genes vital for cancer cell growth and function could be an effective treatment, but there are several challenges which must be overcome to...

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Detalles Bibliográficos
Publicado en:Nucleic Acids Res
Main Authors: Nanna, Alex R, Kel’in, Alexander V, Theile, Christopher, Pierson, Justin M, Voo, Zhi Xiang, Garg, Ashish, Nair, Jayaprakash K, Maier, Martin A, Fitzgerald, Kevin, Rader, Christoph
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2020
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7261152/
https://ncbi.nlm.nih.gov/pubmed/32347936
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa286
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