Synthesis and Characterization of Fluorine-18 labeled N-(4-Chloro-3-((fluoromethyl-d(2))thio)phenyl)picolinamide for Imaging of mGluR4 in Brain

We have synthesized and characterized [(18)F]-N-(4-chloro-3-((fluoromethyl-d(2))thio)phenyl)-picolinamide ([(18)F]15) as a potential ligand for the PET imaging of mGluR4 in the brain. Radioligand [(18)F]15 displays CNS drug-like properties, including mGluR4 affinity, potent mGluR4 PAM activity and s...

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Vydáno v:J Med Chem
Hlavní autoři: Wang, Junfeng, Qu, Xiying, Shoup, Timothy M., Yuan, Gengyang, Afshar, Sepideh, Pan, Chuzhi, Zhu, Aijun, Choi, Ji-Kyung, Kang, Hye Jin, Poutiainen, Pekka, ElFakhri, Georges, Zhang, Zhaoda, Brownell, Anna-Liisa
Médium: Artigo
Jazyk:Inglês
Vydáno: 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7261135/
https://ncbi.nlm.nih.gov/pubmed/32081008
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.0c00201
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