Human islets contain a subpopulation of glucagon-like peptide-1 secreting α cells that is increased in type 2 diabetes

OBJECTIVES: Our study shows that glucagon-like peptide-1 (GLP-1) is secreted within human islets and may play an unexpectedly important paracrine role in islet physiology and pathophysiology. It is known that α cells within rodent and human pancreatic islets are capable of secreting GLP-1, but littl...

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Detalhes bibliográficos
Publicado no:Mol Metab
Main Authors: Campbell, Scott A., Golec, Dominic P., Hubert, Matt, Johnson, Janyne, Salamon, Nicole, Barr, Amy, MacDonald, Patrick E., Philippaert, Koenraad, Light, Peter E.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2020
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7260680/
https://ncbi.nlm.nih.gov/pubmed/32413586
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2020.101014
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