Human islets contain a subpopulation of glucagon-like peptide-1 secreting α cells that is increased in type 2 diabetes

OBJECTIVES: Our study shows that glucagon-like peptide-1 (GLP-1) is secreted within human islets and may play an unexpectedly important paracrine role in islet physiology and pathophysiology. It is known that α cells within rodent and human pancreatic islets are capable of secreting GLP-1, but littl...

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Publicat a:Mol Metab
Autors principals: Campbell, Scott A., Golec, Dominic P., Hubert, Matt, Johnson, Janyne, Salamon, Nicole, Barr, Amy, MacDonald, Patrick E., Philippaert, Koenraad, Light, Peter E.
Format: Artigo
Idioma:Inglês
Publicat: Elsevier 2020
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7260680/
https://ncbi.nlm.nih.gov/pubmed/32413586
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2020.101014
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